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While lower-depend MBL rarely progresses to CLL, large-depend MBL progresses to CLL requiring therapy in a charge of 1% to two% each year. Superior-rely MBL is distinguished from Rai 0 CLL dependant on if the B-mobile rely is higher than or under five × 109/L. Whilst folks with equally higher-depend MBL and CLL Rai phase 0 are at increased danger